"Instructor" Molecule Discovered That Makes Blood Vessel Cells Form Tube-Like Structures

�How do blood watercraft cells translate that they should organize themselves in tubes and not in layers? A research group from Uppsala University shows for the first clock time that a special type of "teacher" molecule is needed to accomplish this. These findings, published in the scientific journal Blood, might be an authoritative step towards using bow cells to build new organs.



In order for a body to develop and function the cells in the soundbox must be able to organise themselves in relation to each other. The way in which cells are staged depends on the electronic organ where they are situated. Blood watercraft cells motivation to strain three-dimensional, vasiform structures that can tape drive blood. But how do blood vas cells know that they should do that? An important part of the communication between cells and their environs is the use of growth factors. These are proteins that bind to receptors on the surface of the cell that receives the information. When the receptor in turn over forms a complex with other proteins, on the inside of the cell, the readout from the DNA hindquarters be altered. The information has "arrived".



VEGF (vascular endothelial growth factor) is a family of closely related growth factors that control blood vessel cells throughout life. Blood vessel development in the foetus as well as later in life, for example during wound healing, is regulated by VEGF. In the present study the research group has examined how VEGF tin can instruct blood vessel cells to arrange themselves into a tube. The answer is that some variants of VEGF have the ability to attract another protein, an instructor molecule, which is joined in concert with VEGF and its reeptor. The combination of instructor molecule, VEGF and receptor results in that a specific signal is sent inner the stock vessel cells, making them form a tube. Without the teacher molecule the cells line up side by side to each other, in a layer.



These results may become very useful. Today stem cells are used to produce new cells, organs and even tissues, that in the future might be used to for transplanting instead of donated organs. If a patient's own stem cells are secondhand the job with electronic organ rejection is avoided. But so far there has been a challenge to create third-dimensional structures from stem cells.



Our contribution lavatory make it possible to create blood line vessels from stem cells and to direct them to kind a tube-shaped structure instead of a layer. Perhaps this knowledge can buoy be transferred to the formation of other tubelike structures in the body, such as the lung and intestines. The perspectives for the future are very exciting, says Lena Claesson-Welsh, world Health Organization has light-emitting diode the study.





Source: Kerstin Henriksson

Uppsala University




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Mp3 music: Steve Vai

Artist: Steve Vai: mp3 download    Genre(s):  Rock Instrumental Rock: Hard-Rock Rock: Progressive Rock: Guitar Virtuoso     Steve Vai's discography:      Sound Theories, Volume 2 - ''Shadows and Sparks''    Year: 2007    Tracks: 6      Sound Theories, Volume 1 - ''The Aching Hunger''    Year: 2007    Tracks: 11      Real Illusions: Reflections    Year: 2005    Tracks: 11      The Infinite Steve Vai: An Anthology (CD 2)    Year: 2004    Tracks: 15      The Infinite Steve Vai: An Anthology (CD 1)    Year: 2004    Tracks: 17      The Elusive Light and Sound Vol. 1 (Part 3)    Year: 2002    Tracks: 13      The Elusive Light and Sound Vol. 1 (Part 2)    Year: 2002    Tracks: 13      The Elusive Light and Sound Vol. 1 (Part 1)    Year: 2002    Tracks: 14      The 7th Song: Enchanting Guitar Melodies - Archive    Year: 2000    Tracks: 10      7th Song: Enchanting Guitar Melodies Archives Vol. 1    Year: 2000    Tracks: 11      The Ultra Zone    Year: 1999    Tracks: 13      Fire Garden    Year: 1996    Tracks: 18      Alien Love Secrets    Year: 1995    Tracks: 7      Sex and Religion    Year: 1993    Tracks: 13      Passion and Warfare    Year: 1990    Tracks: 14      Flex-Able Leftovers    Year: 1984    Tracks: 13 Along with his erstwhile teacher Joe Satriani, six-string virtuoso Steve Vai seat the banner for rock'n'roll music guitar virtuosity in the '80s. Born on June 6, 1960, and raised in Carle Place, NY, Vai became interested in the guitar via such fabled artists as Jimi Hendrix, Led Zeppelin, and Alice Cooper as a stripling and, upon starting high school school, took lessons with an elder histrion from his aged high school school, Joe Satriani. Playing in various local bands, Vai apace picked up on the cat's-paw, and by the eld of 18 was attending the famed Berklee School of Music in Boston. As a bookman there, Vai canned several of Frank Zappa's most technically demanding compositions for guitar, and regular sent a written matter of i such transcription, "Black Page," to Zappa himself. Zappa was so impressed with the young guitar histrion that upon group merging him, he invited Vai to link his stria. Later on, Vai toured the populace with Zappa (giving Vai the nicknames "Stunt Guitarist" and "Little Italian Virtuoso") and played on such albums as 1981's Tinsel Town Rebellion and You Are What You Is, 1982's Ship Arriving Too Late, 1983's Man from Utopia, asset 1984's Them or Us and Thing Fish, earlier going away to set out on his own. First off was a partner off of self-financed, recorded, and released solo albums in 1984, Flex-Able and Flex-Able Leftovers, both of which showcased Vai's guitar playacting and songwriting talents, until now were motionless heavily influenced byZappa. With Van Halen all the madness by the mid-'80s due to their massive toilsome rock/pop crossover success, Vai replaced Yngwie Malmsteen in a similarly styled kit called Alcatrazz (which featured previous Rainbow vocalizer Graham Bonnett), playing on their unnoted 1985 freeing Distressful the Peace. The same year, Vai made a cameo appearance in the motion picture Juncture (playing the devil's guitarist and shredding away in a guitar duel with Ralph Macchio) and got an invite from his friend/bass maestro Billy Sheehan to seek out for the guitar pip in singer David Lee Roth's solo band (Philip Milton Roth had merely rent from Van Halen), and finally landed the fishgig. 1986 adage the debut release from Roth and his astral solo band, Eat 'Em and Smile, which went on to suit one of the year's top difficult john Rock releases. Both Vai and Sheehan were catapulted to superstardom referable to their instrumental talents, as they took top honors in numerous guitar magazines for days afterwards. Merely although the quartet showed smashing promise, Sheehan jumped ship exactly subsequently their sophomore record album, Skyscraper, was issued in 1988. Although the album was more pop-based than its predecessor, it became another ample hit -- with Vai earning a co-producing deferred payment on the album along with Roth. The same class, Vai issued his have railway line of snazzy guitars, the Jem 777 series, via the Ibanez company. After the ensuing go with Roth absorbed up in late 1988, it was Vai's turn to leap transport. In addition to running on another solo record album, he was invited to fall in up with chart-topping pop-metallists Whitesnake, an extend he recognized. His one and only if album with Whitesnake, Parapraxis of the Tongue, was issued in 1989, as was his third solo album overall, Passion and Warfare, a year by and by. The album was based on dreams that Vai experient as a adolescent, as the largely instrumental record album became a goodly attain, earning gold certificate and curing Vai's standing as one of the top guitarists of the day. It was besides around this time that Vai created a seven-string guitar through Ibanez. Although the tool didn't catch on initially, it would by the mid to recent '90s, when the guitarists in such alloy acts as Korn and Limp Bizkit would utilize the instrument to attain super-low tunings. After an extended foramen, Vai formed his number one conventional rock band (called...VAI) along with newcomer Devin Townsend on vocals, T.M. Stevens on bass, and Terry Bozzio on drums -- offering their one and only album in 1993, Sex activity & Religion. When the album proved to be a disappointment both critically and commercially, Vai returned back to all-instrumental exploit with the 1995 EP Alien Love Secrets. For the oddment of the ten, Vai continued to egress solo releases, including 1996's Fire Garden, 1998's Flex-Able Leftovers (a re-release of his long out of print second solo album, with added tracks), and 1999's The Ultra Zone. It was besides during the late '90s that Vai and Satriani reunited for an yearly co-headlining go (with a different third creative person added each class), called G3, unleashing a live album, G3: Live in Concert, in 1997. The early twenty-first century proverb a ado of releases from Vai, including a compiling of instrumentals, The seventh Song: Enchanting Guitar Melodies Archive, in 2000, and his number one full-length live release, Alive in an Ultra World, in 2001, as well as his mammoth career-encompassing ten-disc box determine The Secret Jewel Box. In 2002, he equanimous several pieces that he had contributed to films through the years, including the guitar duel from Crossroads and the melodic theme to Federal Reserve note and Ted's Bogus Journey and place them together in a 40-track accumulation called The Elusive Light and Sound, Vol. 1. A series of compilations came next and subsequently a five-year respite from the studio, Vai returned in 2005 with Real Illusions: Reflections. A turn with the Metropole Orchestra followed and he released a challenging double live determine documenting his performances, coroneted Sound Theories, Vols. twelve, in 2007. Over the long time, Vai guested on unnumerable albums by other artists, including Gregg Bissonette's self-titled debut and Submarine, Alice Cooper's Hey Stoopid, Randy Coven's Casimir Funk Me Tender, Al di Meola's Countless Desire, Public Image Ltd.'s Album, Joe Jackson's Symphony 1, and Billy Sheehan's Compression. He can likewise be ground on such additional Zappa releases as Jazz from Hell, Exclude Up 'N Play Yer Guitar, Guitar, and on several volumes of the ongoing You Can't Do That on Stage Anymore series and the live protection phonograph record, Zappa's Universe. As if his busy schedule weren't full enough, Vai pursued a lifelong interest when he began harvest honey among five-spot bee colonies in the backyard of his rest home.

Oasis star hits out at Winehouse

Noel Gallagher has slated his colleague artists on Chris Moyles' BBC Radio breakfast show, comparing troubled singer Amy Winehouse to a "poverty-stricken horse".

The Oasis star went on to criticise producer Mark Ronson, who remixed The Zutons track Valerie for Winehouse.

He said: "He wants to write his have tunes instead of laying waste everyone else's. Mark Ronson needs to learn three chords on the guitar and write a tune."

Of the Kaiser Chiefs, he said: "The Monkees haven't split up, they're just going under the name of the Kaiser Chiefs."

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Sina Vodjani

   
Artist: Sina Vodjani

   Genre(s): 
New Age
   Easy Listening
   

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Discography:


   
 Karma Love and Compassion Cd2 Compassion

   Year: 2004   
Tracks: 13


   
 Karma Love and Compassion Cd1 Love

   Year: 2004   
Tracks: 15


   
 Sacred Buddha

   Year: 2002   
Tracks: 11


   
 Healing The Heart

   Year: 2002   
Tracks: 15


   
 El Vuelo Del Chaman

   Year: 2002   
Tracks: 18


   
 Om-Shanti

   Year: 1998   
Tracks: 8


   
 Bird Of Hope

   Year: 1998   
Tracks: 10


   
 Karmapa Secret of the crystal

   Year: 1996   
Tracks: 12


   
 No Buddha

   Year:    
Tracks: 11

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Amelia Cuni and Werner Durand and Marika Falk

   
Artist: Amelia Cuni and Werner Durand and Marika Falk

   Genre(s): 
Ethnic
   

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Discography:


   
 Drumming Breath

   Year: 1999   
Tracks: 6

---

 

Corinne returns to the spotlight

HEARTBROKEN singer CORINNE BAILEY RAE is returning to the spotlight for the
first time since the shock death of her husband JASON RAE.

The singer/songwriter was widowed when her saxophonist hubby was found dead in
a Leeds flat earlier this year, with preliminary pathologist reports
suggesting his tragic death could have been caused by an excess of drugs and
drink.

The young couple met at university, marrying when Corinne was 22.

Jason's band HAGGIS HORNS had played with AMY WINEHOUSE, LILY
ALLEN and MARK RONSON - who attended his funeral in April just as
Corinne fled the music scene in order to grieve.

But the Put Your Records On star is set to make her first live appearance to
play on Channel 4's Live From Abbey Road TV show, filmed at the London
recording studio made famous by the BEATLES.

She will join legendary jazz musician HERBIE HANCOCK to play the set on
Thursday.

Barbra Streisand - Streisand Wants To Help Obama

BARBRA STREISAND is in negotiations to offer aid and support to BARACK OBAMA as he campaigns to become America's next President.

The legendary diva's spokeswoman has confirmed that Streisand and Obama are talking about how she can best be used in the Senator's race for the White House.

The singer, a fervent Democrat and longtime friend of Obama's recent party rival Hillary Clinton, is expected to perform at one of the Senator's upcoming fundraisers.

Obama already has plenty of top-name celebrity supporters - Bruce Springsteen, Bob Dylan, Chuck Berry, Oprah Winfrey, Jessica Alba, Scarlett Johansson and Will Smith have all publicly voiced their support for the presidential wannabe.

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Jack Johnson, Sleep Through The Static

So at last the ex-surfer and green activist singer-songwriter delivers his dubstep metal album…Oh alright, Sleep Through…isn't a whole lot different from the Hawaii-born musician's previous outings. Depending on whether you’re a fan this could be good or bad. It's so easy to point to Johnson and cry 'bland!' or 'cozy!', but it's hard to argue with a multi-platinum track record. His status as a household name will be undoubtedly reinforced by this well-nigh perfect example of all his best traits.

While Johnson has one mode of expression – a lazy, loping, bluesy feel underpinned with chiming acoustics and lightly brushed skins, never burdened with tricky key changes of rhythmic surprises – he does it excessively well. True, his delivery often falls on the wrong side of 'safe'. One longs for at least one ruggedly uptempo track filled with righteous bile. Yet, as Johnson himself states in Same Girl: ''I'm not a very good fighter am I?''

Johnson's admirable agenda of eco-love (a typical surfer’s stance, along with the vaguely cod-Zen philosophising) is well represented (All At Once) as are his anti-war feelings (the title track), but Sleep Through…is really the work of a man dealing with the dreadful burden of domestic bliss. It's filled with songs about his wife (Angel) and children (Go On). But then again, why not? It would be so easy to label Johnson as some bland poster boy for middle class mediocrity, yet a closer glimpse at his lyrics show a man who has both a soul and a brain. The only danger is that his style is so relaxed that the message often gets lost in the warmth of it all. Musically (the speed going from slow to fairly slow) it becomes an unvariegated lump of acoustic comfort: Charming but lacking a little bite. Yet it's expertly delivered.

That's what he’s good at. We should be thankful that someone so prominent is both concerned for the planet and our hearts. As long as you’re not expecting to be drastically challenged you’re in safe hands. And sometimes that's quite enough.

Naomi Campbell recovering following operation

Supermodel Naomi Campbell is recuperating after being discharged from hospital following surgery.
Last week, she underwent four-and-a-half hours of surgery at a hospital in Sao Paulo, Brazil, to remove a cyst.
The hospital said over the weekend that Campbell had recovered "very well" and left in a helicopter after being discharged on Friday afternoon.
Mirtes Bogea, spokeswoman for the Sirio Libanes hospital, said: "Doctors signed her release and she left in the afternoon in a helicopter that someone sent to pick her up."
Meanwhile Campbell hit out at "ludicrous" reports she was planning a party.
The Brazilian press reported that the 37-year-old planned to throw a lavish party on the day she left hospital.
But the model said in a statement: "I take my health very seriously, so to suggest that I would host a party following an operation is ludicrous.
"I would like to thank everyone for their kind wishes and concern over the past week and for the fantastic service I have received at the hospital. I will now be recuperating in private."
The Streatham-born model underwent a four-and-a-half hour laparoscopy procedure on Monday.
A friend said: "The suggestion that she would throw a party as soon as she leaves is ridiculous and makes light of what she has been through over the last few days."

Burning Flames

   
Artist: Burning Flames

   Genre(s): 
Other
   

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Discography:


   
 Debble Ish Rage

   Year: 2004   
Tracks: 16

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From Antigua, this isthmus represents the paradigm of the high-energy, multiple-influenced, synthesizer-driven soca bands of close to of the other soca islands. Years of tourer gigs and a stint as computing device backup set up to Montserrat calypsonian Arrow laid the foundation for their solo debut ... add up domination of the Antigua circus in 1986 with Stiley Tight. Elements of rock, funk, reggae, cadency, zouk, and to a greater extent, delegate to frantic tempos of amphetamine-like proportion, were the trademark of this dance band until 1989's "Workey Workey," a funky, zoukish second-line that was an international maven. They zouked it out farther in 1990 with "Chook and Drudge" and before long afterwards were anthologized on a Mango exit, Stab, although the re-mixing through for the record worked to the detriment of for each one slue. They induce interpreted Antigua Route Master of Architecture virtually every yr since 1985.





Slowdive

Winehouse's mother says she's recovering

Winehouse's mother says she's recovering

Amy Winehouse's mother Janis has spoken about her daughter's Grammy achiever, saying that she believes the vocaliser is on "the road to recovery".
Winehouse picked up five-spot Grammy awards only could non give ear the ceremony in Los Angeles because of visa problems. She performed at the event via orbiter from Greater London.
Speaking on 'GMTV', Janis Winehouse said: "Well, as you saw, she looks good and it's a case of she's on the route, and that's what it's around, she's on the road to convalescence."
"I think it would have been as well much for her because whole of the travel and flying at that place, I intend eyesight what the Grammys was like... we could see it live from there and I thought if Amy were thither, she'd be doomed in it, she'd be a little daughter lost in it."
Speech production around her daughter's Grammys performance, she said: "Well, it's Amy advent back, she's by all odds on the way back."
The star's mother besides rundle about her fears for her daughter's wellness before she entered rehab, saying: "She was kind of with it only non with it, and that's the thing where I guess fortuitously, give thanks good in our kinsfolk, she's got a solid family and we're wholly on that point for her."




Brule'

Pat Benatar

   
Artist: Pat Benatar

   Genre(s): 
Rock: Pop-Rock
   Rock
   

---

Discography:


   
 Greatest Hits

   Year: 2005   
Tracks: 20


   
 Go

   Year: 2003   
Tracks: 12


   
 The Very Best Of, Vol. 1

   Year: 1994   
Tracks: 18


   
 Gravity's Rainbow

   Year: 1993   
Tracks: 12


   
 Wide Awake In Dreamland

   Year: 1988   
Tracks: 10


   
 Seven The Hard Way

   Year: 1985   
Tracks: 10


   
 Tropico

   Year: 1984   
Tracks: 10


   
 Get Nervous

   Year: 1982   
Tracks: 10


   
 Precious Time

   Year: 1981   
Tracks: 9


   
 Crimes Of Passion

   Year: 1980   
Tracks: 10


   
 In The Heat Of The Night

   Year: 1979   
Tracks: 10

---

Tap Benatar's dressed mainstream pop/rock made her i of the to a greater extent than popular female vocalists of the betimes '80s. Although she came on like an celestial sphere rocker with her major power chords, yobbo sex, and potent vocals, her medicine was straightaway pop/rock underneath altogether the bluster. Born Patricia Andrzejewski on January 10, 1953, in Greenpoint, Brooklyn, the vocaliser was brocaded in the nearby town of Lindenhurst on Long Island, NY. Benatar began gabble regularly in the Freshly York Metropolis area by the '70s, where she was ascertained at the Catch a Ascent Star club and signed by Chrysalis Records. Backed by a stellar stripe light-emitting junction rectifier by guitar player Neil Geraldo (world Health Organization the singer would later crochet up with) that provided the gross support that was able to effortlessly take turns between rockers and ballads. Benatar quickly conventional herself as unity of rock's crest vocalists, leveling a arrive at right of the cricket bat with her debut album, 1979's In the Heat of the Night, which spawned such tuner pass receiver favorites as "Heartbreaker" and "I Pauperism a Lover" (the latter of which was written by a then-unknown John Mellencamp).


Benatar's soph attempt, 1980's Crimes of Passion, more than delivered on the debut's promise and it's often considered to be the finest transcription of her life history. Spurred on by such classical rock radio set up standards as "Hit Me With Your Best Shot," "Treat Me Decent," and "You Better Ladder," the album was certifiable atomic numeral 78 shortly later its loss and Benatar became a certified bowl star in the U.S. Benatar too became peerless of the most-played artists during MTV's too soon age, received respective Grammy Awards around this metre, and continued to enthral massive hits and sold-out tours throughout the early to mid-'80s, including such albums as 1981's Cherished Time, 1982's Draw Nervous, 1983's Alive from Terra firma, 1984's Tropico, 1985's 7 the Hard Way, and 1988's Broad Waken in Dreamworld, plus the singles "Flame & Sparkler," "Promises in the Shadow," "Shadows of the Night," "Love Is a Field of honor," "We Belong," and "Invincible." Only by the end of the decennium, it appeared as though Benatar had fallen of the font of the Globe as the hits seemed to dry out up.


Benatar opted to shift musical theater gears and progeny an record album of vapors and R&B, 1991's Genuine Love, which failed to yield the isaac Bashevis Isaac Merrit Singer second to the summit meeting of the charts. Benatar returned play on to her patented scene of action stone sound with such further studio releases as 1993's Gravity's Rainbow and 1997's Innamorata (although the latter of which was largely acoustic-based) and spell the albums didn't exactly beat up to her earlier releases, both were solid efforts. The deep '90s saw a partner off of live archival releases strike felon criminal record fund shelves, 1998's 8-15-80 and 1999's The Riley B King Biscuit Bloom Hour Live, in gain to unnumberable hits collections (although the c. H. Charles Herbert Best of the crowd proven to be 1989's Best Shots, which clay a stabilise vendor to this day). The singer began touring one time once again by the midsection of the decade (afterward pickings a five-year hiatus from the route), co-headlining shows with REO Speedwagon, Fleetwood Mackintosh, the Steve Henry Valentine Miller Band, and River Styx. She likewise continued to splash around in playing, appearance in the ABCs Afterschool Special Lacerate Between Two Fathers and on diverse sitcoms. In August 2003, Benatar returned to transcription with Go (Vanguard), her low power train studio apartment LP since 1997's Innamorata. The LP revisited the bowl rock/MOR phone that had defined Benatar's vocation, and was accompanied by an extensive spell.

Frida Kahlo - Passion for Life CONCERT GALA 2008

Frida Kahlo - Passion for Life CONCERT GALA 2008

Freshly York, Apr 9, 2008 -- Natural's Skin Care and Frida
Kahlo Store ar proud to announce the Frida Kahlo - Heat for Animation
Concert Gala 2008 for the benefit of The Cancer of the blood & Lymphoma Guild. It
will take place on Apr 30th at The Renaissance, located at 2131 Hylan
Avenue, Staten Island, Freshly York, at 7:30 pm. This concert is part of the
company's annual charity programme, in order to contribute with the solution
of health and mixer problems.

The event will consist of a dinner-concert where guests volition have the
chance to take component part in the raffle of different products donated by the
sponsoring companies.

Special guests such as Angelo Venuto's "Voices" band, Judy Torres and
the "Tottenville High school women's choir" will be there.

Natural's Tegument Aid and Frida Kahlo Storehouse invite you to a lovely
evening, dedicated to a noble causal agent.

Please contact us at 718-608-9880 x114 for ticket purchases and media
attendance.

Media contact: Kim Bartolone

Tel: 718-608-9880 ext: 114

E post:

Domna Samiou

   
Artist: Domna Samiou

   Genre(s): 
Ethnic
   

---

Discography:


   
 Greek Songs Of Asia Minor

   Year:    
Tracks: 20

---

 

Doherty kicked out of plush pad

Doherty kicked out of plush pad

In the news: Think back the leafy Wiltshire prop Pete Doherty hired when he last came come out of rehab? Sixer months on and it's covered in blood and hombre