�How do blood watercraft cells translate that they should organize themselves in tubes and not in layers? A research group from Uppsala University shows for the first clock time that a special type of "teacher" molecule is needed to accomplish this. These findings, published in the scientific journal Blood, might be an authoritative step towards using bow cells to build new organs.
In order for a body to develop and function the cells in the soundbox must be able to organise themselves in relation to each other. The way in which cells are staged depends on the electronic organ where they are situated. Blood watercraft cells motivation to strain three-dimensional, vasiform structures that can tape drive blood. But how do blood vas cells know that they should do that? An important part of the communication between cells and their environs is the use of growth factors. These are proteins that bind to receptors on the surface of the cell that receives the information. When the receptor in turn over forms a complex with other proteins, on the inside of the cell, the readout from the DNA hindquarters be altered. The information has "arrived".
VEGF (vascular endothelial growth factor) is a family of closely related growth factors that control blood vessel cells throughout life. Blood vessel development in the foetus as well as later in life, for example during wound healing, is regulated by VEGF. In the present study the research group has examined how VEGF tin can instruct blood vessel cells to arrange themselves into a tube. The answer is that some variants of VEGF have the ability to attract another protein, an instructor molecule, which is joined in concert with VEGF and its reeptor. The combination of instructor molecule, VEGF and receptor results in that a specific signal is sent inner the stock vessel cells, making them form a tube. Without the teacher molecule the cells line up side by side to each other, in a layer.
These results may become very useful. Today stem cells are used to produce new cells, organs and even tissues, that in the future might be used to for transplanting instead of donated organs. If a patient's own stem cells are secondhand the job with electronic organ rejection is avoided. But so far there has been a challenge to create third-dimensional structures from stem cells.
Our contribution lavatory make it possible to create blood line vessels from stem cells and to direct them to kind a tube-shaped structure instead of a layer. Perhaps this knowledge can buoy be transferred to the formation of other tubelike structures in the body, such as the lung and intestines. The perspectives for the future are very exciting, says Lena Claesson-Welsh, world Health Organization has light-emitting diode the study.
Source: Kerstin Henriksson
Uppsala University
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Friday 5 September 2008
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